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Abstract #0516

Functional consequences of neurite orientation dispersion and density in humans across the adult lifespan

Arash Nazeri 1,2 , M. Mallar Chakravarty 3,4 , David J. Rotenberg 1 , Tarek K. Rajji 1 , Yogesh Rathi 5 , Oleg V. Michailovich 6 , and Aristotle N. Voineskos 1

1 Centre for Addiction and Mental Health, Toronto, ON, Canada, 2 Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 3 Department of Psychiatry, McGill University, Montreal, QC, Canada, 4 Cerebral Imaging Centre, Douglas Institute, Verdun, QC, Canada, 5 Laboratory of Mathematics in Imaging, Harvard Medical School, Boston, MA, United States, 6 Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON, Canada

Post-mortem studies have documented age-related neocortical dendritic deficits, while compensatory dendritic changes appear to take place in other regions. By applying the neurite-orientation dispersion and density imaging (NODDI) model to multi-shell diffusion images, we found an in vivo pattern aligned very closely with the postmortem data indexing neocortical vulnerability and hippocampal compensation. We further demonstrated that these microstructural changes have consequences in cognitive-function, and brain resting-state networks with known age-related susceptibility.

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