Abstract #0592
Cortical depth dependence of physiological fluctuations and whole-brain resting-state functional connectivity at 7T
Jonathan R. Polimeni 1 , Marta Bianciardi 1 , Boris Keil 1 , and Lawrence L. Wald 1,2
1
Athinoula A. Martinos Center for Biomedical
Imaging, Department of Radiology, Harvard Medical
School, Massachusetts General Hospital, Charlestown,
Massachusetts, United States,
2
Harvard-MIT
Division of Health Sciences and Technology,
Massachusetts Institute of Technology, Cambridge,
Massachusetts, United States
Physiological noise fluctuations are driven by several
mechanisms, and their effects have been shown to vary
across brain regions. Here we investigate the
contribution of several physiological noise sources on
resting-state BOLD as a function of cortical depth. We
find that all physiological measurements, including
cardiac, respiratory, and end-tidal CO2, explain a
higher percentage of the signal variance in BOLD signal
sampled near to the pial surface compared to near the
white matter interface. However, a depth-dependent
seed-based analysis of the Default Mode Network showed
only a modest effect of sampling depth. Target audience:
Clinicians/researchers using high resolution fMRI, or
studying physiological noise in fMRI signals.
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