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Abstract #0592

Cortical depth dependence of physiological fluctuations and whole-brain resting-state functional connectivity at 7T

Jonathan R. Polimeni 1 , Marta Bianciardi 1 , Boris Keil 1 , and Lawrence L. Wald 1,2

1 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, United States, 2 Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States

Physiological noise fluctuations are driven by several mechanisms, and their effects have been shown to vary across brain regions. Here we investigate the contribution of several physiological noise sources on resting-state BOLD as a function of cortical depth. We find that all physiological measurements, including cardiac, respiratory, and end-tidal CO2, explain a higher percentage of the signal variance in BOLD signal sampled near to the pial surface compared to near the white matter interface. However, a depth-dependent seed-based analysis of the Default Mode Network showed only a modest effect of sampling depth. Target audience: Clinicians/researchers using high resolution fMRI, or studying physiological noise in fMRI signals.

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