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Abstract #0602

Functional Pathways in Monkey Brain Mapped Using Resting State Correlation Tensors

Tung-Lin Wu 1 , Feng Wang 1,2 , Li Min Chen 1,2 , Adam W. Anderson 1,2 , Zhaohua Ding 1,2 , and John C. Gore 1,2

1 Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2 Radiology and Radiological Sciences, Vanderbilt Univeristy, Nashville, TN, United States

Recently, we reported that anisotropic correlations between resting state signals within a local region of white matter can be used to drive functional structures that closely resemble DTI data but without the use of diffusion gradients. Indeed, we demonstrated a technique that delineates the functional architecture of the brain, especially white matter, purely on the basis of fMRI data. In order to explore and verify the biophysical mechanisms for the observed spatio-temporal correlations in white matter signals, we carried out imaging studies on live anesthetized squirrel monkeys and compared spatio-temporal correlation tensors from T2* and cerebral blood volume (CBV)-weighted fMRI.

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