Abstract #0610
High plasma flow as measured using DCE-MRI and the 2CXM is associated with increased disease-free survival in patients with carcinoma of the cervix
Ben R Dickie 1 , Lucy E Kershaw 1 , Stephanie Withey 2 , Bernadette M Carrington 3 , Catharine M West 4 , and Chris J Rose 5
1
Medical Physics and Engineering, Christie
NHS Foundation Trust, Manchester, United Kingdom,
2
RRPPS,
University Hospitals Birmingham NHS Foundation Trust,
Birmingham, United Kingdom,
3
Department
of Radiology, Christie NHS Foundation Trust, Manchester,
United Kingdom,
4
Institute
of Cancer Sciences, University of Manchester,
Manchester, United Kingdom,
5
Centre
for Imaging Sciences, University of Manchester,
Manchester, United Kingdom
DCE-MRI studies of cervical cancer have reported that
Tofts model-derived
K
trans
may
predict outcome. Since
K
trans
depends
on both microvascular perfusion and permeability, it is
unclear whether one or both are important for predicting
survival. We present what we believe to be the first
prospective DCE-MRI study (n = 42) to employ the more
specific two-compartment exchange model (2CXM) to
separately measure perfusion (plasma flow) and
permeability, and study their relationship to
disease-free survival. High plasma flow (
P
=
0.022) and low FIGO stage (
P
=
0.020) were significant predictors of survival, but
permeability was not (
P
=
0.63).
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