Meeting Banner
Abstract #0666

Comparing Functional Tumor Volume and Pharmacokinetic Parameter in DCE-MRI Prediction of Breast Cancer Therapy Response: A Preliminary Study

Alina Tudorica 1 , David C Newitt 2 , Karen Y Oh 1 , Nicole Roy 1 , Stephen Y-C Chui 1 , Arpana Naik 1 , Megan L Troxell 1 , Yiyi Chen 1 , Aneela Afzal 1 , Megan L Holtorf 1 , Nola M Hylton 2 , and Wei Huang 1

1 Oregon Health & Science University, Portland, OR, United States, 2 University of California, San Francisco, CA, United States

High-temporal-resolution (17-20 s) DCE-MRI data were collected from 14 breast cancer patients (15 tumors) before and after one cycle of neoadjuvant chemotherapy. The original data were analyzed with pharmacokinetic (PK) modeling, while the resampled low-temporal-resolution (80-100 s) data were used to quantify functional tumor volumes (FTV) based on threshold values of early percent signal change and signal enhancement ratio. Empirical analysis based FTV metrics performed comparably for early prediction of pathologic response in comparison with quantitative PK parameters.

This abstract and the presentation materials are available to members only; a login is required.

Join Here