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Abstract #0670

Quantitative Perfusion Measurements in Renal Masses with Arterial Spin Labeling and Dynamic Contrast Enhanced MRI at 3T Correlate with Microvessel Density at Histopathology

Yue Zhang 1 , Payal Kapur 2,3 , Qing Yuan 1 , Ananth Madhuranthakam 1,4 , Ingrid Carvo 5 , Sabina Signoretti 5 , Ivan Dimitrov 6 , Yin Xi 1 , Katherine Wicks 1 , Jeffrey Cadeddu 1,3 , Vitaly Margulis 3 , James Brugarolas 7,8 , and Ivan Pedrosa 1,4

1 Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2 Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 3 Urology, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 4 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 5 Pathology, Brigham and Womens Hospital, Boston, Massachusetts, United States, 6 Philips Medical Systems, Cleveland, Ohio, United States, 7 Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 8 Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States

Our aim was to investigate the correlation between in vivo perfusion measurement of renal masses by arterial spin labeling (ASL) and dynamic contrast-enhanced (DCE) MRI at 3T and validate these results against microvessel density (MVD) at histopathology. Quantitative ASL perfusion ( P ASL ) and DCE parameters were obtained from the whole tumor, and from areas with high- and low- perfusion within the tumor. ASL measured blood flow in renal masses correlates with DCE-derived parameters. P ASL , K trans , and Kep correlate with MVD. ASL and DCE MRI at 3T provide a tool for assessing angiogenesis in renal cancer.

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