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Abstract #0672

Evaluation of Stretched-Exponential Model for Diffusion-Weighted Imaging of breast lesions Using High b Values: comparison with monoexponential Diffusion Weighted Imaging

Chunling Liu 1 , Changhong Liang 1 , Yingjie Mei 2 , Zaiyi Liu 1 , and Jine Zhang 1

1 Department of Radiology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China, 2 Philips Healthcare, Guangzhou, Guangdong, China

Breast cancer is the most commonly diagnosed type of cancers of women. In this study, we obtained the parameters (ADCs and ) information using a stretched-exponential model with high b-values for normal breast and breast lesions and compared them to apparent diffusion coefficient (ADC) with conventional DWI in their ability to discriminate benign lesions and malignant tumors. 77 patients underwent a standard bilateral breast MRI examination including DWI sequence and ADCs, and ADC were obtained according to different diffusion models. The statistical analysis results suggest that ADCs of the stretched model can be used to differentiate benign and malignant lesions and has the highest specificity, comparing the conventional ADC, however, is not different between benign and malignant tumors and may be further investigated.

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