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Abstract #0711

In Vivo Diffusion-Weighted MRI: Contrast-Free Detection of Myocardial Fibrosis in Hypertrophic Cardiomyopathy Patients

Christopher Nguyen 1 , Minjie Liu 2,3 , Zhaoyang Fan 1 , Xiaoming Bi 4 , Peter Kellman 5 , Debiao Li 1 , and Shihua Zhao 2,3

1 Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States, 2 State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Beijing, China, 3 National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 4 Siemens Healthcare, Los Angeles, CA, United States, 5 National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States

In 23 hypertrophic cardiomyopathy (HCM) patients, we applied a recently developed 3D motion compensated diffusion-prepared balanced steady-state free precession technique to detect diffuse myocardial fibrosis and compared it against extracellular volume (ECV) mapping and late gadolinium enhanced (LGE) imaging. The proposed technique quantitatively had excellent agreement with ECV (sensitivity, specificity, PPV, NPV, and accuracy: 0.80, 0.85, 0.81, 0.85, and 0.83 with Kappa > 0.66) and yielded increased apparent diffusion coefficient values in regions with elevated ECV (>30%). The proposed cardiac diffusion technique is a contrast-free approach that can detect diffuse myocardial fibrosis in HCM patients comparable to ECV.

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