Abstract #0711
In Vivo Diffusion-Weighted MRI: Contrast-Free Detection of Myocardial Fibrosis in Hypertrophic Cardiomyopathy Patients
Christopher Nguyen 1 , Minjie Liu 2,3 , Zhaoyang Fan 1 , Xiaoming Bi 4 , Peter Kellman 5 , Debiao Li 1 , and Shihua Zhao 2,3
1
Biomedical Imaging Research Institute,
Cedars Sinai Medical Center, Los Angeles, CA, United
States,
2
State
Key Laboratory of Cardiovascular Disease, Fuwai
Hospital, Beijing, China,
3
National
Center for Cardiovascular Diseases, Chinese Academy of
Medical Sciences and Peking Union Medical College,
Beijing, China,
4
Siemens
Healthcare, Los Angeles, CA, United States,
5
National
Heart, Lung, and Blood Institute, National Institutes of
Health, Bethesda, MD, United States
In 23 hypertrophic cardiomyopathy (HCM) patients, we
applied a recently developed 3D motion compensated
diffusion-prepared balanced steady-state free precession
technique to detect diffuse myocardial fibrosis and
compared it against extracellular volume (ECV) mapping
and late gadolinium enhanced (LGE) imaging. The proposed
technique quantitatively had excellent agreement with
ECV (sensitivity, specificity, PPV, NPV, and accuracy:
0.80, 0.85, 0.81, 0.85, and 0.83 with Kappa > 0.66) and
yielded increased apparent diffusion coefficient values
in regions with elevated ECV (>30%). The proposed
cardiac diffusion technique is a contrast-free approach
that can detect diffuse myocardial fibrosis in HCM
patients comparable to ECV.
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