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Abstract #0724

Age-related changes of the human brain: Insights from double-wave vector imaging

Marco Lawrenz 1,2 , Stefanie Brassen 1,2 , and Jrgen Finsterbusch 1,2

1 Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany, 2 Neuroimage Nord, University Medical Centers Hamburg-Kiel-Lbeck, Hamburg-Kiel-Lbeck, Hamburg-Kiel-Lbeck, Germany

Double-wave-vector diffusion-weighting experiments with two weighting periods applied successively offer access to microscopic tissue. Rotationally invariant measures of the microscopic diffusion anisotropy such as the MA index may yield additional information complementary to DTI. Recent studies showed that MA can be determined in the living human brain, and normal values and their variation in a group of young healthy volunteers have been reported. In this study, DWV and DTI measurements were performed in a group of old, healthy volunteers in order to detect age-related changes of the FA and MA.

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