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Abstract #0740

Methylphenidate modulates the connectivity of default mode network in ADHD: a resting-state dynamic causal model analysis

Hongjian He 1 , Fangfang Xu 1 , and Jianhui Zhong 1

1 Center for Brain Imaging Science and Technology, Zhejiang University, Hangzhou, Zhejiang, China

This study is interested in the modulatory effect of Methylphenidate in attention deficit hyperactivity disorder. A dynamic causal model analysis was applied to investigated the effective connectivity within default mode network in resting state. Our preliminary study revealed that the causal connectivity is altered by the dose of MPH, in which the inhibitory link from RIPL to MPFC is significantly enhanced.

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