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Abstract #0742

Simultaneous Muscle Water T2 and Fat Fraction Mapping using Transverse Relaxometry with Stimulated Echo Compensation

Benjamin Marty 1,2 , Pierre-Yves Baudin 3 , Noura Azzabou 1,2 , Ericky C.A. Araujo 1,2 , Pierre G. Carlier 1,2 , and Paulo Loureiro de Sousa 4

1 NMR laboratory, Institute of Myology, Paris, France, 2 NMR laboratory, CEA/I2BM/MIRCen, Paris, France, 3 Consultants for Research in Imaging and Spectroscopy, Tournai, Belgium, 4 Universit de Strasbourg, CNRS, ICube, FMTS, Strasbourg, France

Muscle inflammation and fatty infiltrations are indicators of disease activity and progression in neuromuscular disorders. They can respectively be assessed by muscle T2 relaxometry and water/fat separation techniques. T2 is often derived from multiecho spin-echo acquisitions and mono-exponential fitting. However, MSME signal rarely displays a pure spin-echo decay as it is a mix of refocused echoes and stimulated echoes. Recently, it has been proposed to process MSME signal using the Extended Phase Graph (EPG) algorithm to take into account stimulated echo. Here, we implemented a multi-component EPG-fitting to simultaneously quantify the muscle water T2 and fat fraction from MSME acquisitions.

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