Abstract #0846
Characterizing Water Diffusion and Perfusion Features of the Healthy and Malignant Pancreas Using Diffusion-Tensor and Diffusion Weighted MRI
Noam Nissan 1 , Talia Golan 2 , Edna Furman-Haran 1 , Sara Apter 2 , Yael Inbar 2 , Arie Ariche 2 , Barak Bar Zakay 2 , Yuri Goldes 2 , Michael Schvimer 2 , Dov Grobgeld 1 , and Hadassa Degani 1
1
Weizmann Institute of Science, Rehovot,
Israel,
2
Sheba
Medical Center, Israel
The diagnostic utility of 3T abdomen-MR DTI using
b-values (0,100,500) and multi-b DWI were investigated
in the healthy pancreas and pancreatic adenocarcinoma.
Analysis of the DTI and DWI suggested a contribution of
IVIM to the diffusion coefficient of the healthy
pancreas at b<100 s/mm2 leading to a significant
reduction in the diffusion coefficients and increase in
FA at b-values of 100-500s/mm2 compared to 0-500 s/mm2.
Cancer was characterized by lower diffusion coefficients
in both b-sets and a smaller difference in these
coefficients between the two sets, suggesting high
cellularity and decreased perfusion, compared to normal
pancreatic tissue.
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