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Abstract #0846

Characterizing Water Diffusion and Perfusion Features of the Healthy and Malignant Pancreas Using Diffusion-Tensor and Diffusion Weighted MRI

Noam Nissan 1 , Talia Golan 2 , Edna Furman-Haran 1 , Sara Apter 2 , Yael Inbar 2 , Arie Ariche 2 , Barak Bar Zakay 2 , Yuri Goldes 2 , Michael Schvimer 2 , Dov Grobgeld 1 , and Hadassa Degani 1

1 Weizmann Institute of Science, Rehovot, Israel, 2 Sheba Medical Center, Israel

The diagnostic utility of 3T abdomen-MR DTI using b-values (0,100,500) and multi-b DWI were investigated in the healthy pancreas and pancreatic adenocarcinoma. Analysis of the DTI and DWI suggested a contribution of IVIM to the diffusion coefficient of the healthy pancreas at b<100 s/mm2 leading to a significant reduction in the diffusion coefficients and increase in FA at b-values of 100-500s/mm2 compared to 0-500 s/mm2. Cancer was characterized by lower diffusion coefficients in both b-sets and a smaller difference in these coefficients between the two sets, suggesting high cellularity and decreased perfusion, compared to normal pancreatic tissue.

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