Ventilation heterogeneity in obstructive airways disease comparing multi-breath washout-imaging with global lung measurements
Felix C Horn 1 , Helen Marshall 1 , Salman Siddiqui 2 , Alexander Horsley 3 , Laurie Smith 1 , Ina Aldag 4 , Richard Kay 5 , Christopher J Taylor 4 , Juan Parra-Robles 1 , and Jim M Wild 1
Sheffield University, Sheffield, United
of Leicester, United Kingdom,
of Manchester, United Kingdom,
Children's NHS Foundation Trust, NHS, United Kingdom,
Gas washout measured with hyperpolarized helium-3 MRI
can be used to obtain quantitative regional lung
function in 3D (MBW-I). Multiple breath inert gas
washout as clinically performed in the pulmonary
function lab (MBW) is sensitive to early signs of
ventilation heterogeneity in obstructive lung diseases.
In this work MBW-I and MBW were performed in healthy
controls, CF patients and an asthma cohort. Ventilation
heterogeneity as measured by MBW-I was found to
correlate significantly with MBW & spirometry. The MBW-I
derived parameter to measure ventilation heterogeneity
was found to be more sensitive to ventilation
heterogeneity than conventional MBW and spirometry.
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