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Abstract #0852

Ventilation heterogeneity in obstructive airways disease comparing multi-breath washout-imaging with global lung measurements

Felix C Horn 1 , Helen Marshall 1 , Salman Siddiqui 2 , Alexander Horsley 3 , Laurie Smith 1 , Ina Aldag 4 , Richard Kay 5 , Christopher J Taylor 4 , Juan Parra-Robles 1 , and Jim M Wild 1

1 Sheffield University, Sheffield, United Kingdom, 2 University of Leicester, United Kingdom, 3 University of Manchester, United Kingdom, 4 Sheffield Children's NHS Foundation Trust, NHS, United Kingdom, 5 Novartis, Switzerland

Gas washout measured with hyperpolarized helium-3 MRI can be used to obtain quantitative regional lung function in 3D (MBW-I). Multiple breath inert gas washout as clinically performed in the pulmonary function lab (MBW) is sensitive to early signs of ventilation heterogeneity in obstructive lung diseases. In this work MBW-I and MBW were performed in healthy controls, CF patients and an asthma cohort. Ventilation heterogeneity as measured by MBW-I was found to correlate significantly with MBW & spirometry. The MBW-I derived parameter to measure ventilation heterogeneity was found to be more sensitive to ventilation heterogeneity than conventional MBW and spirometry.

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