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Abstract #0864

Pushing X-ray CT out of the equation: In vivo RASOR MRI-based seed detection for post-implant dosimetry in LDR prostate

Peter Roland Seevinck 1 , Cornelis A van den Berg 2 , Frank Zijlstra 1 , Marielle E Philippens 2 , Stan Jelle Hoogcarspel 2 , Jan J Lagendijk 2 , Maximus A Viergever 1 , and Marinus Adriaan Moerland 2

1 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 2 Department of Radiotherapy, University Medical Center Utrecht, Netherlands

This study demonstrates the feasibility of in vivo MRI-based localisation of implanted brachytherapy seeds with positive contrast and high specificity, using a robust, clinically available imaging sequence with RASOR reconstruction and straightforward post-processing. This approach may enable MRI-only postimplant dosimetry, preventing the need for CT-based seed detection and image fusion and all related disadvantages, including radiation exposure, registration errors and additional costs. Interestingly, the optimized RASOR sequence facilitates visualisation of bone structures. As a consequence other applications of the proposed technique may be bone and fiducial imaging for MRI-based treatment planning in external beam radiotherapy and attenuation correction in PET-MRI.

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