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Abstract #0871

Minimally Invasive Magnetic Resonance Imaging-Guided Delivery of Neural Stem Cells into the Porcine Spinal Cord

Jason J Lamanna 1,2 , Lindsey N Urquia 1 , Carl V Hurtig 1 , Juanmarco Gutierrez 1 , Cody Anderson 3 , Pete Piferi 4 , Thais Federici 1 , Nicholas M Boulis 1,2 , and John N Oshinski 2,5

1 Neurosurgery, Emory University, Atlanta, GA, United States, 2 Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, GA, United States, 3 Physics, Emory University, Atlanta, GA, United States, 4 MRI Interventions, Inc., Memphis, TN, United States, 5 Radiology, Emory University, Atlanta, GA, United States

Transplantation of cellular therapeutics to the spinal cord is conventionally done with either systemic administration, or local injection following surgical exposure of the spinal cord. For intraparenchymal transplantation, targeting to the spinal cord is based on a combination pre-operative MRI measurements and anatomical landmarks. Our group developed an MR-compatible spinal cord injection system capable of replacing invasive surgical procedures. Here we present the proof-of-principle for percutaneous, intraparenchymal transplantation of stem cells into the spinal cord of a live Gottingen minipig under MRI guidance.

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