Abstract #0871
Minimally Invasive Magnetic Resonance Imaging-Guided Delivery of Neural Stem Cells into the Porcine Spinal Cord
Jason J Lamanna 1,2 , Lindsey N Urquia 1 , Carl V Hurtig 1 , Juanmarco Gutierrez 1 , Cody Anderson 3 , Pete Piferi 4 , Thais Federici 1 , Nicholas M Boulis 1,2 , and John N Oshinski 2,5
1
Neurosurgery, Emory University, Atlanta, GA,
United States,
2
Biomedical
Engineering, Emory University & Georgia Institute of
Technology, Atlanta, GA, United States,
3
Physics,
Emory University, Atlanta, GA, United States,
4
MRI
Interventions, Inc., Memphis, TN, United States,
5
Radiology,
Emory University, Atlanta, GA, United States
Transplantation of cellular therapeutics to the spinal
cord is conventionally done with either systemic
administration, or local injection following surgical
exposure of the spinal cord. For intraparenchymal
transplantation, targeting to the spinal cord is based
on a combination pre-operative MRI measurements and
anatomical landmarks. Our group developed an
MR-compatible spinal cord injection system capable of
replacing invasive surgical procedures. Here we present
the proof-of-principle for percutaneous,
intraparenchymal transplantation of stem cells into the
spinal cord of a live Gottingen minipig under MRI
guidance.
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