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Abstract #0922

Rapid Multi-Orientation Susceptibility Mapping with Wave-CAIPI

Berkin Bilgic 1 , Luke Xie 2 , Russell Dibb 2 , Christian Langkammer 1 , Aysegul Mutluay 1 , Huihui Ye 1 , Jonathan R Polimeni 1 , Chunlei Liu 2 , Lawrence L Wald 1 , and Kawin Setsompop 1

1 Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 Radiology, Duke University Medical Center, Durham, NC, United States

Rapid 3D-GRE imaging with Wave-CAIPI attains high quality reconstruction at 15-fold acceleration to facilitate fast acquisition of extremely time consuming COSMOS and STI protocols at multiple head orientations. This technique revealed exquisite cortical contrast and detailed depiction of iron rich nuclei; it enabled detection of anisotropic structures such as white matter tracts. Wave-CAIPI permits a 5:35 min acquisition per orientation at 0.5 mm isotropic resolution for COSMOS, and a 90 sec acquisition per orientation at 1.1 mm isotropic resolution for STI. Furthermore, we deployed a novel EPI-FLEET sequence for rapid and low-distortion calibration acquisition, thus enabling coil sensitivity estimation of both head and body coils from a 10 sec scan.

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