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Abstract #0925

B 0 -orientation dependent susceptibility-induced white matter contrast in the human brainstem

Manisha Aggarwal 1 , Xu Li 2 , Susumu Mori 1,2 , and Peter C. M. van Zijl 1,2

1 Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States

In this study, we investigate susceptibility-induced B 0 -orientation dependence of the apparent relaxation rate (R 2 *) and signal frequency measurements in the ex vivo fixed human brainstem. Gradient echo (GRE) data acquired at 11.7T showed distinct modulation of R 2 * and frequency contrasts between the corticospinal and transverse pontine fibers in the brainstem, which closely approximated sin 4 θ and sin 2 θ dependencies on orientation relative to the static B 0 field. We further investigate the estimation of fiber orientation maps based on the modulated R 2 * curves, and compare the results with primary eigenvector maps derived using diffusion MRI.

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