How to suppress the contribution from pseudo-diffusion in oscillating gradient diffusion MRI

Oscillating gradient spin-echo (OGSE) diffusion MRI is useful to probe tissue microstructures at ultra-short diffusion times, and its applications on clinical MR systems are gradually emerging. However, OGSE diffusion measurements are commonly acquired at relatively low b-values due to gradient constraints, and such measurements contain contributions from perfusion related pseudo-diffusion. In this study, we showed the OGSE signals are sensitive to pseudo-diffusion at low b-values, and proposed to use pulsed and oscillating gradient on orthogonal directions to suppress the contributions from pseudo-diffusion. The hybrid sequence may be useful for future applications of OGSE diffusion MRI on clinical scanners.

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