Abstract #0956
How to suppress the contribution from pseudo-diffusion in oscillating gradient diffusion MRI
Dan Wu 1 and Jiangyang Zhang 2
1
Biomedical Engineering, Johns Hopkins
University School of Medicine, BALTIMORE, Maryland,
United States,
2
Radiology,
Johns Hopkins University School of Medicine, Maryland,
United States
Oscillating gradient spin-echo (OGSE) diffusion MRI is
useful to probe tissue microstructures at ultra-short
diffusion times, and its applications on clinical MR
systems are gradually emerging. However, OGSE diffusion
measurements are commonly acquired at relatively low
b-values due to gradient constraints, and such
measurements contain contributions from perfusion
related pseudo-diffusion. In this study, we showed the
OGSE signals are sensitive to pseudo-diffusion at low
b-values, and proposed to use pulsed and oscillating
gradient on orthogonal directions to suppress the
contributions from pseudo-diffusion. The hybrid sequence
may be useful for future applications of OGSE diffusion
MRI on clinical scanners.
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