Abstract #0988
3D mapping of Glutathione in the human brain via real-time motion corrected MEGA-LASER MRSI
Wolfgang Bogner 1 , Bernhard Strasser 1 , Michal Povazan 1 , Gilbert Hangel 1 , Borjan Gagoski 2 , Stephan Gruber 1 , Bruce Rosen 3 , Siegfried Trattnig 1 , and Ovidiu C Andronesi 3
1
MRCE, Department of Biomedical Imaging and
Image-guided Therapy, Medical University Vienna, Vienna,
Vienna, Austria,
2
Fetal-Neonatal
Neuroimaging & Developmental Science Center, Boston
Children's Hospital, Harvard Medical School, Boston, MA,
United States,
3
Athinoula
A. Martinos Center for Biomedical Imaging, Department of
Radiology, Massachusetts General Hospital, Harvard
Medical School, Charlestown, MA, United States
The reduced form of Glutathione (GSH) is the most
important intra-cellular antioxidant that prevents
cellular damage caused by free radicals and peroxides.
GSH can be measured via 1H-MR spectroscopy (MRS), but
its low concentration and spectral overlap with signals
from more abundant compounds require special editing
techniques such as MEGA-PRESS. Previous reports were
mostly limited to single-voxel, a few reported
single-slice-MRS imaging. Here we introduce robust 3D
mapping of brain GSH levels via a MEGA-edited,
spiral-accelerated, real-time motion-&B0-corrected
fully-adiabatic LASER localization sequence. As an
excellent marker for oxidative stress, GSH imaging could
be a powerful non-invasive imaging tool for the
investigation of many neurological disorders.
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