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Abstract #0988

3D mapping of Glutathione in the human brain via real-time motion corrected MEGA-LASER MRSI

Wolfgang Bogner 1 , Bernhard Strasser 1 , Michal Povazan 1 , Gilbert Hangel 1 , Borjan Gagoski 2 , Stephan Gruber 1 , Bruce Rosen 3 , Siegfried Trattnig 1 , and Ovidiu C Andronesi 3

1 MRCE, Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Vienna, Austria, 2 Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 3 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States

The reduced form of Glutathione (GSH) is the most important intra-cellular antioxidant that prevents cellular damage caused by free radicals and peroxides. GSH can be measured via 1H-MR spectroscopy (MRS), but its low concentration and spectral overlap with signals from more abundant compounds require special editing techniques such as MEGA-PRESS. Previous reports were mostly limited to single-voxel, a few reported single-slice-MRS imaging. Here we introduce robust 3D mapping of brain GSH levels via a MEGA-edited, spiral-accelerated, real-time motion-&B0-corrected fully-adiabatic LASER localization sequence. As an excellent marker for oxidative stress, GSH imaging could be a powerful non-invasive imaging tool for the investigation of many neurological disorders.

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