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Abstract #1044

Hypoxia modification during prostate radiotherapy: an evaluation of changes in the tumour microenvironment using multi-parametric MRI (mpMRI)

N Jane Taylor 1 , Kent Yip 2 , Juliette Valentine 2 , J James Stirling 1 , Ian C Simcock 1 , David J Collins 3 , James A d'Arcy 3 , Uma Patel 2 , Andrew Gogbashian 1 , Peter Hoskin 2 , Anwar R Padhani 1 , and Roberto Alonzi 2

1 Paul Strickland Scanner Centre, Mount Vernon Hospital, London, United Kingdom, 2 Marie Curie Research Wing, Mount Vernon Cancer Centre, London, United Kingdom, 3 Cancer Research-UK-EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

Hypoxia correction improves survival in patients treated with radiotherapy (RT) for some cancers. Previous studies have shown the existence of hypoxia in untreated prostate cancer (PCa) and hypoxia resolution following carbogen breathing. Androgen deprivation therapy (ADT) is normally given prior to RT. ADT is anti-angiogenic and causes tumour vascular disruption. It is not known whether the use of carbogen gas will still be effective in correcting hypoxia post ADT. This study has assessed this during hypoxia-modified RT.

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