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Abstract #1079

Breast DCE with Fat Suppression: Enabling Quantitative Measurements

Maria A Schmidt 1 , Eva Kousi 1 , Araminta Ledger 1 , Erica Scurr 2 , Cheryl Richardson 2 , Georgina Hopkinson 2 , Elizabeth O'FLynn 1 , Steven Allen 2 , Romney Pope 2 , Robin Wilson 2 , and M Leach 1

1 CR-UK and EPSRC Cancer Imaging Centre, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 Department of Radiology, Royal Marsden NHS Foundation Trust, Chelsea, London, United Kingdom

Breast Dynamic Contrast-Enhanced (DCE) examinations are usually performed with fat suppression, providing qualitative enhancement curves. In contrast, pharmacokinetic modelling often uses spoiled gradient-echo images and a proton density weighted image as a reference to calculate T1 values. It would be desirable to calculate T1 values from fat suppressed clinical DCE examinations to quantify contrast-agent uptake in longitudinal studies and to assess parenchymal enhancement. In this work we introduce a reference image of low flip angle and a calibration process, and evaluate the accuracy of T1 values thus obtained. T1 measurements are viable in fat suppressed breast DCE.

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