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Abstract #1081

High-resolution Proton Density weighted Dixon sequences maximize precision of breast density measurements

Araminta EW Ledger 1 , Maria A Schmidt 1 , Marco Borri 1 , Erica D Scurr 2 , Julie Hughes 2 , Alison Macdonald 2 , Toni Wallace 2 , Robin Wilson 2 , and Martin O Leach 1

1 CR-UK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom, 2 Radiology, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

Percent-water (%Water) calculated from Dixon fat-water separation techniques can provide a volumetric measurement of breast density, an established risk factor for breast cancer. In this work, we calculate breast %Water in repeat volunteer datasets to evaluate measurement reproducibility from a high-resolution proton-density (PD) weighted two-point Dixon sequence, and assess the error arising at lower spatial resolution and with T1/T2 weighting. %Water measurements from high-resolution PD weighted sequences are found to be highly reproducible. Statistically significant differences in %Water measurement arise at lower spatial resolutions and with the introduction of T1 or T2 weighting, even with correction for fat/water signal differences.

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