Abstract #1081
High-resolution Proton Density weighted Dixon sequences maximize precision of breast density measurements
Araminta EW Ledger 1 , Maria A Schmidt 1 , Marco Borri 1 , Erica D Scurr 2 , Julie Hughes 2 , Alison Macdonald 2 , Toni Wallace 2 , Robin Wilson 2 , and Martin O Leach 1
1
CR-UK Cancer Imaging Centre, The Institute
of Cancer Research and Royal Marsden NHS Foundation
Trust, Sutton, Surrey, United Kingdom,
2
Radiology,
The Royal Marsden NHS Foundation Trust, Sutton, Surrey,
United Kingdom
Percent-water (%Water) calculated from Dixon fat-water
separation techniques can provide a volumetric
measurement of breast density, an established risk
factor for breast cancer. In this work, we calculate
breast %Water in repeat volunteer datasets to evaluate
measurement reproducibility from a high-resolution
proton-density (PD) weighted two-point Dixon sequence,
and assess the error arising at lower spatial resolution
and with T1/T2 weighting. %Water measurements from
high-resolution PD weighted sequences are found to be
highly reproducible. Statistically significant
differences in %Water measurement arise at lower spatial
resolutions and with the introduction of T1 or T2
weighting, even with correction for fat/water signal
differences.
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