Abstract #1092
Monitoring cancer treatment: quantitative MRI of tumor micro-structure and metabolism with chemical exchange saturation transfer and diffusion weighted MRI
Rozhin Yousefi 1 , Xiaoyong Huang 2 , Stanley K. Liu 2 , and Greg J. Stanisz 1,2
1
Medical Biophysics, University of Toronto,
Toronto, Ontario, Canada,
2
Sunnybrook
Research Institute, Toronto, Ontario, Canada
In recent years, the number of available treatment
modalities for cancer has increased significantly while
their effectiveness remains uncertain. Finding a
non-invasive imaging method to provide early assessment
of tumor response to therapy will significantly enhance
treatment outcome. Our proposed method is to apply
quantitative MRI (qMRI) to evaluate tumor
micro-structure and metabolism during treatment using
two MRI techniques: chemical exchange saturation
transfer (CEST) and diffusion weighted MRI (DW-MRI). In
vivo experimental results showed significant differences
in qMRI measurements of tumors including apparent
diffusion coefficient (ADC) and amine CEST peak, before
and after treatment.
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