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Abstract #1092

Monitoring cancer treatment: quantitative MRI of tumor micro-structure and metabolism with chemical exchange saturation transfer and diffusion weighted MRI

Rozhin Yousefi 1 , Xiaoyong Huang 2 , Stanley K. Liu 2 , and Greg J. Stanisz 1,2

1 Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, 2 Sunnybrook Research Institute, Toronto, Ontario, Canada

In recent years, the number of available treatment modalities for cancer has increased significantly while their effectiveness remains uncertain. Finding a non-invasive imaging method to provide early assessment of tumor response to therapy will significantly enhance treatment outcome. Our proposed method is to apply quantitative MRI (qMRI) to evaluate tumor micro-structure and metabolism during treatment using two MRI techniques: chemical exchange saturation transfer (CEST) and diffusion weighted MRI (DW-MRI). In vivo experimental results showed significant differences in qMRI measurements of tumors including apparent diffusion coefficient (ADC) and amine CEST peak, before and after treatment.

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