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Abstract #1103

MRI accurately identifies early murine mammary cancers and reliably differentiates between in situ and invasive cancer: Correlation of MRI with histology

Devkumar Mustafi 1 , Erica Markiewicz 1 , Marta Zamora 1 , Xiaobing Fan 1 , Jeffrey Mueller 2 , Suzanne D Conzen 3 , and Gregory S Karczmar 1

1 Radiology, The University of Chicago, Chicago, IL, United States, 2 Pathology, The University of Chicago, Chicago, IL, United States, 3 Medicine, Section of Hematology and Oncology, The University of Chicago, Chicago, IL, United States

Precise MRI-histopathology correlation demonstrates that MRI accurately identifies mammary cancer at various stages of development in the widely used C3(1)SV40Tag mouse model, and provides a tool for the development of image-based markers that differentiate indolent from aggressive cancer. 96% of in situ and 100% of invasive cancers identified on in vivo MRI agreed with histology. Methods described here will allow investigators to develop better MRI-based markers for tumor progression, improve understanding of cancer initiation and progression, evaluate response to therapy in murine models of breast cancer, and provide valuable insights regarding clinical management of patients with early breast cancers.

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