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Abstract #1113

19F MRSI of capecitabine in the liver using broadband TxRx antennas and dual-frequency excitation pulses at 7T

Jetse van Gorp 1 , Peter Seevinck 1 , Anna Andreychenko 2 , Alexander Raaijmakers 2 , Peter Luijten 3 , Miriam Koopman 4 , Vincent Boer 3 , and Dennis Klomp 3

1 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Department of Radiotherapy, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 3 Department of Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 4 Department of Medical Oncology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands

In this work, the feasibility to detect orally administered chemotherapy (capecitabine) in the liver was investigated at a clinical 7T MR system. The system was equipped with a broadband radiative antenna to acquire both 1H and 19F signal, and dual-frequency excitation pulses were implemented to overcome excitation issues. Pulse acquire and 3D spectroscopic imaging 19F spectra were successfully acquired in two patients at 1 and 10 hours after drug intake. The results show that it is feasible to monitor chemotherapy metabolism at 7T in the human body.

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