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Abstract #1115

cPLA2 inhibition affects the relationship between vascular function and structure in a patient-derived breast cancer model: a correlation study of DCE-MRI vs. micro-CT

Eugene Kim 1 , Astrid Jullumstr Feuerherm 2,3 , Berit Johansen 2,3 , Olav Engebraaten 4 , Gunhild Mari Mlandsmo 4 , Tone Frost Bathen 1 , and Siver Andreas Moestue 1

1 MR Cancer Group, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, 2 Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway, 3 Avexxin AS, Trondheim, Norway, 4 Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway

DCE-MRI and ex vivo micro-CT angiography were used to investigate the relationship between tumor vascular function and structure, and the effect of a cytosolic phospholipase A2 (cPLA2) inhibitor (AVX235, Avexxin AS) on this relationship, in a patient-derived breast cancer model. In control tumors (n=7), there were good correlations between Ktrans and vascular surface area (SA) (r=0.67) and between vp and SA (r=0.7). In AVX235-treated tumors (n=9), these correlations were weaker (r=0.25 and 0.33, respectively). This suggests that cPLA2 inhibition modulated the link between vascular structure and function and had a spatially heterogeneous effect on blood flow and/or vessel permeability.

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