Abstract #1146
Estimation of Fat fractions in Different Subtypes of Breast Cancer using in-vivo 1H MRS Study
Khushbu Agarwal 1 , Uma Sharma 1 , Smriti Hari 2 , Vurthaluru Seenu 3 , Rajinder Parshad 3 , and Naranamangalam R Jagannathan 1
1
Department of NMR & MRI Facility, All India
Institute of Medical Sciences, New Delhi, Delhi, India,
2
Department
of Radiodiagnosis, All India Institute of Medical
Sciences, New Delhi, Delhi, India,
3
Department
of Surgical Disciplines, All India Institute of Medical
Sciences, New Delhi, Delhi, India
Fat fractions were calculated in different molecular
subtypes of breast cancer based on ER, PR and Her2neu
status. It was demonstrated that lipid content is
associated with hormone receptor status of breast cancer
patients. Our results showed a significant increase in
fat fraction of ER-/PR- and Her2neu+ than ER+/PR+ and
Her2neu- breast tumors. Highly proliferating tumors like
ER-, PR- and Her2neu+ breast cancers require more fat
for membrane production. The results obtained in the
present study signifies that studying lipid content of
different breast cancer subtypes might help in
therapeutic planning of these patients.
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