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Abstract #1151

Comparison of prostate tumor volume delineation between multi-parametric MRI sequences when planning for hypofractionated radiotherapy

Hugh Harvey 1 , Veronica Morgan 2 , David Dearnaley 3 , Sharon Giles 2 , Alison Macdonald 2 , Julia Murray 3 , and Nandita deSouza 1

1 CRUK Cancer Imaging Centre, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 The Royal Marsden NHS Foundation Trust, Surrey, United Kingdom, 3 Radiotherapy & Imaging, The Institute of Cancer Research, London, United Kingdom

Delineation of the tumor region-of interest is crucial when planning boost doses of radiation therapy to a dominant intraprostatic tumor nodule. Comparison of prostatic tumor volume measurements defined on T2W images, Apparent Diffusion Coefficient maps and Dynamic Contrast Enhanced images in 16 patients due for radiation dose-boosting to tumor revealed a significant difference in measured volumes between the sequences, with T2W-derived volumes being up to 48.7% larger than DCE-derived volumes and therefore most useful in the context of radiation therapy planning.

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