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Abstract #1153

Bi-exponential diffusion analysis in normal prostate and prostate cancer: transition zone and peripheral zone considerations

Thiele Kobus 1,2 , Andriy Fedorov 1 , Clare Tempany 1 , Robert Mulkern 3 , Ruth Dunne 1 , and Stephan E. Maier 1

1 Radiology, Brigham and Women's Hospital, Boston, Massachusetts, United States, 2 Radiology, Radboud UMC, Nijmegen, Netherlands, 3 Radiology, Children's Hospital, Boston, Massachusetts, United States

We investigated the performance of the bi-exponential fit for extended b-factor DWI (b=0 to 3500 s/mm 2 ) in discriminating between different tissues in prostate imaging. The means of the fitted parameters, ADC fast , ADC slow and f slow (fraction of ADC slow component), were significantly different between normal tissue (PZ and TZ) and tumor tissue in both PZ and TZ. There was also a difference for f slow between normal PZ and TZ (p<0.001). No differences in the parameters were found between tumors in the PZ and TZ. The increase of f slow in tumor tissue might represent the occupation of the luminal space by tumor cells.

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