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Abstract #1162

In Vivo Sodium Imaging of Human Prostate Cancer

Justin Charles Peterson 1 , Adam Farag 2 , Trevor Szekeres 2 , Eli Gibson 2,3 , Aaron D Ward 2,3 , Joseph Chin 4 , Stephen Pautler 5 , Glenn Bauman 4 , Cesare Romagnoli 4 , Robert Bartha 1,2 , and Timothy J Scholl 1,2

1 Medical Biophysics, Western University, London, Ontario, Canada, 2 Robarts Research Institute, Ontario, Canada, 3 Biomedical Engineering, Western University, Ontario, Canada, 4 London Health Sciences Centre, Ontario, Canada, 5 St. Joseph's Health Care, Ontario, Canada

Prostate cancer (PCa) is the most common malignancy in men. Currently, a combination of multi-parametric MR including T 2 -weighted, diffusion-weighted, and dynamic contrast enhanced imaging, is used clinically but often provides insufficient information to determine the malignancy of a lesion. Previous studies have shown increased MRI measured tissue sodium concentration (TSC) in brain and breast cancer. In this report we demonstrate in vivo 23 Na MRI in patients with PCa. Using this proposed method TSC data was registered to histopathology and analyzed. These preliminary data show a positive correlation between tumor grade and TSC within the prostate.

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