Abstract #1164
Using Multiparametric MRI to Differentiate Prostate Cancer in the Anterior Aspect of the Gland
Olga Starobinets 1,2 , Jeffry Simko 3,4 , Kyle Kuchinsky 3 , Sonam Machingal 1 , John Kurhanewicz 1,2 , Peter R Carroll 4 , Kirsten L Greene 4 , and Susan M Noworolski 1,2
1
Radiology and Biomedical Imaging, UCSF, San
Francisco, CA, United States,
2
Graduate
Group in Bioengineering, UC Berkeley, Berkeley, CA,
United States,
3
Pathology,
UCSF, San Francisco, CA, United States,
4
Urology,
UCSF, San Francisco, CA, United States
The purpose of this study was to use semi-quantitative
parameters derived from dynamic contrast-enhanced (DCE)
MRI, 1hydrogen-MR spectroscopic imaging (MRSI),
diffusion MR and MRI to differentiate benign and
malignant, as well as high-risk from low-risk prostate
cancers in the anterior aspect of the prostate using
whole-mount pathology as the standard of reference. A
logistic regression combination of parameters provided
ROC AUC=0.983 for discriminating benign from malignant
tissues and AUC=0.824 for distinguishing between
low-risk and high-risk cancer.
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