Simultaneous time-resolved measurement of blood flow, perfusion and oxygen consumption in lower leg during recovery from exercise.
Adil Bashir 1 , Robert Gropler 1 , and Jie Zheng 1
Mallinckrodt Institute of Radiology,
Washington University, St. Louis, MO, United States
Chronic disease such as heart failure, diabetes,
peripheral artery disease etc. negatively impact muscle
blood flow (BF) and perfusion and thereby lead to
metabolic disorders, diminished exercise capacity and
tissue loss. In this work, we have developed a
time-resolved method to measure BF, perfusion and oxygen
(O2) consumption simultaneously in lower leg during
recovery from plantar flexion exercises. The feasibility
and reproducibility of the proposed method is
demonstrated in six healthy subjects. This method will
shed light on the interplay between muscle function and
substrate delivery and will lead to new pathways to
exploit for diagnostics and therapeutics.
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