Simultaneous time-resolved measurement of blood flow, perfusion and oxygen consumption in lower leg during recovery from exercise.

Chronic disease such as heart failure, diabetes, peripheral artery disease etc. negatively impact muscle blood flow (BF) and perfusion and thereby lead to metabolic disorders, diminished exercise capacity and tissue loss. In this work, we have developed a time-resolved method to measure BF, perfusion and oxygen (O2) consumption simultaneously in lower leg during recovery from plantar flexion exercises. The feasibility and reproducibility of the proposed method is demonstrated in six healthy subjects. This method will shed light on the interplay between muscle function and substrate delivery and will lead to new pathways to exploit for diagnostics and therapeutics.

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