Abstract #1205
Robust T2 mapping of knee cartilage under in situ mechanical loading using prospective motion correction
Thomas Lange 1 , Michael Herbst 1,2 , Benjamin R. Knowles 1 , Kaywan Izadpanah 3 , and Maxim Zaitsev 1
1
Department of Radiology, Medical Physics,
University Medical Center Freiburg, Freiburg, Germany,
2
John
A. Burns School of Medicine, University of Hawaii,
Honolulu, Hawaii, United States,
3
Department
of Orthopedic and Trauma Surgery, University Medical
Center Freiburg, Freiburg, Germany
Cartilage T2 has been established as a sensitive
biomarker, which correlates with collagen
microarchitecture and water content and is thus
susceptible to loading. In this work, we demonstrate
robust T2 mapping of the patellofemoral cartilage with
in situ mechanical loading, using prospective motion
correction of load-induced subject motion. T2 maps are
reconstructed from multiple spin-echo data for scans
with slice position updates before every excitation and
scans with additional inter-echo correction. While
uncorrected images show considerable motion artifacts
giving rise to erroneous cartilage T2 mapping results,
these artifacts can be efficiently suppressed with
prospective motion correction.
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