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Abstract #1205

Robust T2 mapping of knee cartilage under in situ mechanical loading using prospective motion correction

Thomas Lange 1 , Michael Herbst 1,2 , Benjamin R. Knowles 1 , Kaywan Izadpanah 3 , and Maxim Zaitsev 1

1 Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 2 John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States, 3 Department of Orthopedic and Trauma Surgery, University Medical Center Freiburg, Freiburg, Germany

Cartilage T2 has been established as a sensitive biomarker, which correlates with collagen microarchitecture and water content and is thus susceptible to loading. In this work, we demonstrate robust T2 mapping of the patellofemoral cartilage with in situ mechanical loading, using prospective motion correction of load-induced subject motion. T2 maps are reconstructed from multiple spin-echo data for scans with slice position updates before every excitation and scans with additional inter-echo correction. While uncorrected images show considerable motion artifacts giving rise to erroneous cartilage T2 mapping results, these artifacts can be efficiently suppressed with prospective motion correction.

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