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Abstract #1207

T1 measurements in the intervertebral discs: Analysis of reproducibility and diurnal changes

Volkan Emre Arpinar 1 , Weitian Chen 2 , and L Tugan Muftuler 1,3

1 Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 2 Global Applied Science Laboratory, GE Healthcare, California, United States, 3 Center for Imaging Research, Medical College of Wisconsin, Milwaukee, WI, United States

It was shown that MRI T1Rho images could be used to assess proteoglycan loss; therefore, it can be employed as a quantitative measure of intervertebral discs (IVD) degeneration, especially in early stages. In order to use T1Rho as a diagnostic or prognostic tool, however, one needs to assess the reproducibility of these measurements. Moreover, earlier studies showed diurnal changes in the IVDs during rest and loading conditions. Therefore the goal of this work was to assess the reproducibility and diurnal changes in T1Rho measurements in the IVDs.

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