Abstract #1214
Non-Gaussian diffusion weighted imaging for assessing degenerative changes in intervertebral disc composition
Masaki Katsura 1,2 , Yuichi Suzuki 2 , Akihiro Kasahara 2 , Harushi Mori 1 , Akira Kunimatsu 1 , Yoshitaka Masutani 3 , Masaaki Hori 4 , Shigeki Aoki 4 , and Kuni Ohtomo 1
1
Radiology, Graduate School of Medicine, The
University of Tokyo, Tokyo, Japan,
2
Radiology,
The University of Tokyo Hospital, Tokyo, Japan,
3
Intelligent
Systems, Hiroshima City University, Hiroshima, Japan,
4
Radiology,
School of Medicine, Juntendo University, Tokyo, Japan
In the present study, we performed q-space imaging (QSI)
analyses for lumbar intervertebral discs (IVDs) with
different stages of degeneration. Our results suggest
that the degenerative process of IVDs involves narrowing
of the space for free water movement and a generally
higher degree of microstructural complexity, in which we
are unable to assess with conventional quantitative MR
measurements. QSI may provide sensitive biomarkers for
IVD degenerative microstructural changes and can
potentially become an appropriate tool to allow
characterization of various IVD pathologies.
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