Abstract #1223
Mr Diffusion Is Sensitive To Mechanical Loading In Human Intervertebral Disks
Ron N Alkalay 1 , Carl-Fredrik Westin 2 , Dominik Meier 2 , and David B Hackney 3
1
Orthopedics, Beth Israel Deaconess Medical
Center, Boston, MA, United States,
2
Radiology,
Brigham and Women's Hospital, Boston, MA, United States,
3
Radiology,
Beth Israel Deaconess Medical Center, Boston, MA, United
States
Human disks were MR imaged using T2map and MR
diffusivity protocols under two load conditions and the
disks dynamic and viscoelastic response quantified.
Loading yielded significantly lower Mean Diffusivity and
higher variance. No such changes were observed for
T2map. Tissue based differences (Nucleus vs. Annulus)
were observed for both measures, but only diffusivity
detected the application of loading. MD correlated with
the disks dynamic and viscoelastic response with T2
relaxation correlated with its dynamic and long-term
viscoelastic response. The strong correlations between
MD and disk mechanics suggest that MR might permit
quantitative assessment of disk functional status and
structural integrity.
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