Muscular fat fraction determination by quantitative T2-MRI, reproducibility in facioscapulohumeral muscular dystrophy and healthy volunteers

The aim of this study was to assess the reproducibility of quantitative T2-MRI determined muscular fat fraction in patients with fascioscapulohumeral muscular dystrophy (FSHD) and healthy volunteers. Fat content was derived from multi spin-echo images of 80 FSHD muscles and 45 healthy volunteer muscles by fitting the signal-intensity to a bi-exponential function with fixed T2 times for muscle and fat. Reproducibility was assessed by a Bland-Altman analysis. The coefficient of repeatability for FSHD muscles and healthy muscles were 6.5% (1.96*SD) and 2.8% (1.96*SD), respectively. With this reproducibility, treatment effects of 2.5% can be detected in a patient cohort < 10.

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