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Abstract #1231

MRI characterization of individual muscles in patients with sporadic inclusion body myositis (sIBM) using a semi-automatic segmentation approach

Didier Laurent 1 , Attila Nagy 2 , Steve Pieper 2 , Harlem Gongxeka 1 , Celeste Pretorius 1 , and Stefan Baumann 1

1 Biomarker Department, Novartis, Basel, Switzerland, 2 Isomics, Inc, Cambridge, Ma, United States

A 3D semi-automated segmentation approach was developed and validated for quick and accurate determination of individual thigh muscle volumes from magnetic resonance (MR) image series of both healthy individuals and patients with sporadic inclusion body myositis (sIBM). Specific muscles of sIBM patients displayed clear signs of atrophy, more so in the anterior compartment of the thigh, along with up to 50% of infiltrated fat, which might explain propensity of these patients to loose balance.

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