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Abstract #1241

MR characterization of murine model of dystrophy on a DBA background

Ravneet Vohra 1 , Sean Forbes 2 , Krista Vandenborne 3 , Elizabeth Mcnally 4 , and Glenn Walter 5

1 Physiology and Functional Genomics, University of Florida, Gainesville, Florida, United States, 2 Physical Therapy, University of Florida, Gainesville, Florida, United States, 3 Physical Therapy, University of Florida, Florida, United States, 4 Department of Medicine, University of Chicago, Chicago, Illinois, United States, 5 Physiology and Functional Genomics, Unversity of Florida, Gainesville, Florida, United States

Mutations in the genes encoding dystrophin and its associated proteins cause muscular dystrophies, which are characterized by progressive muscle weakness and replacement by fibrotic tissue. Genetic modifiers have been shown to influence phenotypic variability both in humans and animal models. In animal models genetic modifiers can be studied by knocking out the same gene on different background of mouse strain. Murine models of muscular dystrophy on typical C57 background show relatively less severity over their life span compared to mouse models on DBA/2 background. In this study we used magnetic resonance to characterize murine models of dystrophy on DBA background.

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