Abstract #1241
MR characterization of murine model of dystrophy on a DBA background
Ravneet Vohra 1 , Sean Forbes 2 , Krista Vandenborne 3 , Elizabeth Mcnally 4 , and Glenn Walter 5
1
Physiology and Functional Genomics,
University of Florida, Gainesville, Florida, United
States,
2
Physical
Therapy, University of Florida, Gainesville, Florida,
United States,
3
Physical
Therapy, University of Florida, Florida, United States,
4
Department
of Medicine, University of Chicago, Chicago, Illinois,
United States,
5
Physiology
and Functional Genomics, Unversity of Florida,
Gainesville, Florida, United States
Mutations in the genes encoding dystrophin and its
associated proteins cause muscular dystrophies, which
are characterized by progressive muscle weakness and
replacement by fibrotic tissue. Genetic modifiers have
been shown to influence phenotypic variability both in
humans and animal models. In animal models genetic
modifiers can be studied by knocking out the same gene
on different background of mouse strain. Murine models
of muscular dystrophy on typical C57 background show
relatively less severity over their life span compared
to mouse models on DBA/2 background. In this study we
used magnetic resonance to characterize murine models of
dystrophy on DBA background.
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