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Abstract #1266

Diffusion MRI identifies enhanced connection of neural pathways in toddlers with Autism Spectrum Disorder

J. Mitra 1 , E. Conti 2,3 , K-K. Shen 1 , J. Fripp 1 , O. Salvado 1 , S. Calderoni 2 , A. Guzzetta 2,3 , and S. Rose 1

1 Australian e-Health & Research Centre, CSIRO Digital Productivity Flagship, Herston, QLD, Australia, 2 Dept. of Developmental Neuroscience, Stella Maris Scientific Institute, Pisa, Italy, 3 University of Pisa, Pisa, Italy

Autism Spectrum Disorder (ASD) is a heterogeneous group of neuro-developmental diseases and is characterized by impairment in socio-communicative abilities, as well as restricted and stereotyped behaviours. There is a growing interest in identifying structural and functional neuro-anatomical correlates of the disorder that has the potential to predict early behavioural assessment impacting tailored rehabilitation intervention. In this study we analyse the diffusion MRI of ASD and developmental delay (DD) infants below 36 months of age and compare the differences in neural pathways using network based statistics. Further we analyse the asymmetry between the two cohorts from the obtained neural pathways.

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