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Abstract #1292

Multi-parametric Magnetic Resonance to Investigate Aggression: A Study at 11.7T on the BALB/cJ Mouse Model

Houshang Amiri 1,2 , Amanda Jager 2 , Sjaak J. A. van Asten 1 , Arend Heerschap 1 , and Jeffrey Glennon 2

1 Department of Radiology, Radboud University Medical Center, Nijmegen, Gelderland, Netherlands, 2 Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, Gelderland, Netherlands

Aggressive behaviour is a key symptom of conduct disorder (CD). Therefore, animal models of aggression could provide more knowledge about the neural substrates underlying CD and could provide new insights in possible treatments to treat or prevent this disorder. We first extensively phenotyped the BALB/cJ mice (as an aggressive model) in terms of aggression, anxiety, impulsivity, compulsivity and attention. Then, a multiparametric MR experiment including DTI, ASL, and MRS was performed. Our findings suggest that pathological aggression observed in the BALB/cJ mice is likely related to structural and neurochemical changes leading to inattention and anxiety.

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