Abstract #1302
Causal brain correlates of autonomic nervous system outflow
Andrea Duggento 1 , Marta Bianciardi 2 , Lawrence L. Wald 2 , Luca Passamonti 3 , Riccardo Barbieri 4,5 , Maria Guerrisi 1 , and Nicola Toschi 1,2
1
Medical Physics Section, Department of
Biomedicine and Prevention, University of Rome "Tor
Vergata", Rome, Italy,
2
Department
of Radiology, A.A. Martinos Center for Biomedical
Imaging, MGH and Harvard Medical School, Boston, MA,
United States,
3
Institute
of Bioimaging and Molecular Physiology, National
Research Council, Catanzaro, Italy,
4
Department
of Anesthesia and Critical Care, Massachusetts General
Hospital, Boston, MA, United States,
5
Department
of Brain and Cognitive Science, Massachusetts Institute
of Technology, Cambridge, MA, United States
We use 7T fMRI with simultaneous physiological signals
acquisitions to investigate the causal interactions
between resting state brain activity and autonomic
nervous system (ANS) outflow as quantified through a
probabilistic heartbeat model. We demonstrate the
existence of significant causal links between
cortical/subcortical brain regions and ANS outflow for
(para)sympathetic modulation as well as sympathovagal
balance, with a prominent involvement of cerebellar
regions and Sensory Motor, Default Mode, Left executive
and Right executive networks. 7T functional imaging
coupled with Granger causality estimates is able to
quantify directed brain-heart interactions reflecting
directed central modulation of ANS outflow.
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