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Abstract #1310

Choline a differential marker of glutamatergic neurotransmission ?

Anke Henning 1,2 , Simone Grimm 3,4 , Erich Seifritz 3 , and Milan Scheidegger 2,3

1 Max Planck Institut for Biological Cybernetics, Tuebingen, Baden-Wuertemberg, Germany, 2 Institute for Biomedical Engineering, UZH and ETH Zurich, Zurich, Zurich, Switzerland, 3 Department of Psychiatry, Psychotherapy, and Psychosomatics, University Hospital of Psychiatry Zurich, Zurich, Switzerland, 4 Clinic for Psychiatry and Psychotherapy, Charite Berlin, Berlin, Germany

In this work, we demonstrate that the cerebral Cho concentration is related to adaptive changes in neurotransmitter and more specifically glutamate secretion. To this we used the NMDA-receptor antagonist ketamine as a tool compound, which was previously shown by invasive methods to largely increase synaptic glutamate release.

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