Abstract #1310
Choline a differential marker of glutamatergic neurotransmission ?
Anke Henning 1,2 , Simone Grimm 3,4 , Erich Seifritz 3 , and Milan Scheidegger 2,3
1
Max Planck Institut for Biological
Cybernetics, Tuebingen, Baden-Wuertemberg, Germany,
2
Institute
for Biomedical Engineering, UZH and ETH Zurich, Zurich,
Zurich, Switzerland,
3
Department
of Psychiatry, Psychotherapy, and Psychosomatics,
University Hospital of Psychiatry Zurich, Zurich,
Switzerland,
4
Clinic
for Psychiatry and Psychotherapy, Charite Berlin,
Berlin, Germany
In this work, we demonstrate that the cerebral Cho
concentration is related to adaptive changes in
neurotransmitter and more specifically glutamate
secretion. To this we used the NMDA-receptor antagonist
ketamine as a tool compound, which was previously shown
by invasive methods to largely increase synaptic
glutamate release.
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