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Abstract #1316

NODDI Measures Appear to be Sensitive to Both Age and Gender

Chandana Kodiweera 1 , Andrew Alexander 2 , and Yu-Chien Wu 3

1 Dartmouth Brain Imaging Center, Dartmouth College, Hanover, NH, United States, 2 Waisman Brain Imaging Lab, University of Wisconsin, Madison, Wisconsin, United States, 3 Center for Neuroimaging, Indiana University, Indianapolis, Indiana, United States

Fractional anisotropy (FA) may depend not only on the fiber orientation but also on the axonal density. In the case of a white matter disease, a change in either fiber orientation or axonal density will result a change in FA value. The orientation dispersion index and intra-cellular volume fraction, two tissue specific measures from NODDI model, can be used to study changes in fiber orientation and axonal density. In this study, aging data collected using a multiple shell acquisition scheme (HYDI) was analyzed using FA, odi and icvf to see how age and gender affect in these measures.

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