Abstract #1316
NODDI Measures Appear to be Sensitive to Both Age and Gender
Chandana Kodiweera 1 , Andrew Alexander 2 , and Yu-Chien Wu 3
1
Dartmouth Brain Imaging Center, Dartmouth
College, Hanover, NH, United States,
2
Waisman
Brain Imaging Lab, University of Wisconsin, Madison,
Wisconsin, United States,
3
Center for
Neuroimaging, Indiana University, Indianapolis, Indiana,
United States
Fractional anisotropy (FA) may depend not only on the
fiber orientation but also on the axonal density. In the
case of a white matter disease, a change in either fiber
orientation or axonal density will result a change in FA
value. The orientation dispersion index and
intra-cellular volume fraction, two tissue specific
measures from NODDI model, can be used to study changes
in fiber orientation and axonal density. In this study,
aging data collected using a multiple shell acquisition
scheme (HYDI) was analyzed using FA, odi and icvf to see
how age and gender affect in these measures.
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