Abstract #1331
Age-related increased R2 and R2* correlates with increased brain iron in a normal ageing mouse model
Thomas Walker 1 , Christos Michaelides 1 , Harry Parkes 2 , William Crum 1 , Tina Geraki 3 , Amy Herlihy 4 , and Po-Wah So 1
1
Department of Neuroimaging, Institute Of
Psychiatry, King's College London, London, United
Kingdom,
2
CR-UK,
Clinical MR Research Group, Institute of Cancer
Research, Sutton, Surrey, United Kingdom,
3
Diamond
Light Source, Harwell Science and Innovation Campus,
Didcot, Oxfordshire, United Kingdom,
4
Agilent
Technologies, Yarnton, Oxfordshire, United Kingdom
Brain iron accumulation with ageing may play a role in
senescent processes, with age-related increases in basal
ganglia R2 and R2* observed in man and associated with
increased iron. Here, we show similar increases in R2
and R2* in the basal ganglia of ageing C57BL/6J mice.
Quantitatively measured increased iron by synchrotron
radiation X-ray fluorescence elemental iron mapping
suggests the increased R2 and R2* values may indeed
arise from higher iron concentrations. Thus, iron
dyshomeostasis may play a role in ageing and MR
relaxometry may be used to monitor these ageing
processes.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
