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Abstract #1331

Age-related increased R2 and R2* correlates with increased brain iron in a normal ageing mouse model

Thomas Walker 1 , Christos Michaelides 1 , Harry Parkes 2 , William Crum 1 , Tina Geraki 3 , Amy Herlihy 4 , and Po-Wah So 1

1 Department of Neuroimaging, Institute Of Psychiatry, King's College London, London, United Kingdom, 2 CR-UK, Clinical MR Research Group, Institute of Cancer Research, Sutton, Surrey, United Kingdom, 3 Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom, 4 Agilent Technologies, Yarnton, Oxfordshire, United Kingdom

Brain iron accumulation with ageing may play a role in senescent processes, with age-related increases in basal ganglia R2 and R2* observed in man and associated with increased iron. Here, we show similar increases in R2 and R2* in the basal ganglia of ageing C57BL/6J mice. Quantitatively measured increased iron by synchrotron radiation X-ray fluorescence elemental iron mapping suggests the increased R2 and R2* values may indeed arise from higher iron concentrations. Thus, iron dyshomeostasis may play a role in ageing and MR relaxometry may be used to monitor these ageing processes.

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