Abstract #1348
Multiparametric MRI assessment of chronic social defeat-induced changes in mouse brain function, metabolism, and structure
Joanes Grandjean 1 , Damiano Azzinnari 2 , Aline Seuwen 1 , Erich Seifritz 2 , Christopher Pryce 2 , and Markus Rudin 3,4
1
Institute for Biomedical Engineering, ETH
and University Zurich, Zurich, Switzerland,
2
Psychiatric
University Hospital Zurich, Zurich, Switzerland,
3
Institute
for Biomedical Engineering, ETH and University Zurich,
Zurich, Select, Switzerland,
4
Institute
of Pharmacology and Toxicology, University Zurich,
Zurich, Switzerland
A chronic social defeat (CSD) mouse model has
demonstrated that chronic social stress induces
depression-relevant behavior as well as changes related
to the immune and dopamine systems. We have
characterized the functional, metabolic, and structural
changes occurring in mice following CSD using
fMRI/MRS/MRI. We report alterations in the functional
networks, in particular in the cingulate and prefrontal
cortex. Fractional anisotropy was increased in the
cingulum fibers of CSD mice compared to controls.
Finally, inositol concentration was increased in the CSD
mice. These reports compare well reports of functional
alteration in the default mode network in humans with
depressive disorders.
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