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Abstract #1348

Multiparametric MRI assessment of chronic social defeat-induced changes in mouse brain function, metabolism, and structure

Joanes Grandjean 1 , Damiano Azzinnari 2 , Aline Seuwen 1 , Erich Seifritz 2 , Christopher Pryce 2 , and Markus Rudin 3,4

1 Institute for Biomedical Engineering, ETH and University Zurich, Zurich, Switzerland, 2 Psychiatric University Hospital Zurich, Zurich, Switzerland, 3 Institute for Biomedical Engineering, ETH and University Zurich, Zurich, Select, Switzerland, 4 Institute of Pharmacology and Toxicology, University Zurich, Zurich, Switzerland

A chronic social defeat (CSD) mouse model has demonstrated that chronic social stress induces depression-relevant behavior as well as changes related to the immune and dopamine systems. We have characterized the functional, metabolic, and structural changes occurring in mice following CSD using fMRI/MRS/MRI. We report alterations in the functional networks, in particular in the cingulate and prefrontal cortex. Fractional anisotropy was increased in the cingulum fibers of CSD mice compared to controls. Finally, inositol concentration was increased in the CSD mice. These reports compare well reports of functional alteration in the default mode network in humans with depressive disorders.

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