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Abstract #1355

Reproducibility of metabolite measurements in patients with schizophrenia at 7T

Subechhya Pradhan 1 , Joseph S Gillen 1,2 , S. Andrea Wijtenburg 3 , Ashley D Harris 1 , Laura M Rowland 3 , and Peter B Barker 1,2

1 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 2 Kennedy Krieger Institute, Baltimore, Maryland, United States, 3 Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, United States

MR spectroscopy is an important tool for the non-invasive measurement of brain metabolite levels in various neuropsychiatric disorders. Knowledge of the reproducibility of metabolite measurements in patients is important in studying metabolite changes due to disease progression and/or treatment. In this study, we assess the 1-week reproducibility of the metabolite concentration measurements made at 7 Tesla using the semi-LASER and STEAM sequences, in a cohort of subjects with stable, chronic schizophrenia.

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