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Abstract #1366

Real-time fMRI Neurofeedback with Simultaneous EEG in Combat-related PTSD: Identification of EEG Measures of PTSD Severity and Treatment Response

Vadim Zotev 1 , Raquel Phillips 1 , Masaya Misaki 1 , Chung Ki Wong 1 , Brent Wurfel 1 , Matthew Meyer 1,2 , Frank Krueger 1,3 , Matthew Feldner 1,4 , and Jerzy Bodurka 1,5

1 Laureate Institute for Brain Research, Tulsa, OK, United States, 2 Laureate Psychiatric Clinic and Hospital, Tulsa, OK, United States, 3 Neuroscience Dept., George Mason University, Fairfax, VA, United States, 4 Dept. of Psychological Science, University of Arkansas, Fayetteville, AR, United States, 5 College of Engineering, University of Oklahoma, Tulsa, OK, United States

We have performed emotion regulation training in veterans with combat-related PTSD using real-time fMRI neurofeedback (rtfMRI-nf) with simultaneous EEG. Six PTSD patients learned to upregulate their left amygdala activity using rtfMRI-nf during a positive emotion induction task based on retrieval of happy autobiographical memories. We observed task-dependent variations in frontal EEG asymmetry (FEA) in the upper alpha band that correlated with PTSD severity (CAPS). Individual changes in CAPS ratings significantly correlated with changes in FEA variations. The results suggest that variations in FEA during rtfMRI-nf training may provide a sensitive measure of PTSD severity and individual response to treatment.

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