Abstract #1371
Multimodal quantitative imaging detects functional but not structural abnormalities in idiopathic generalized epilepsy
Megan L. McGill 1 , Orrin Devinsky 2 , Xiuyuan Wang 2 , Brian T. Quinn 2 , Heath Pardoe 2 , Chad Carlson 2 , Tracy Butler 2 , Ruben Kuzniecky 2 , and Thomas Thesen 2
1
Radiology, New York University School of
Medicine, New York, NY, United States,
2
Comprehensive
Epilepsy Center, Neurology, New York University School
of Medicine, New York, NY, United States
This study employs functional and anatomic analysis of
MRI scans to detect focal and network abnormalities in
Idiopathic Generalized Epilepsy (IGE), a diffuse
neurologic disorder characterized by normal appearing
clinical MRI scans. Analysis of resting state functional
MRI, diffusion tensor imaging, and quantitative
morphometric analysis shows that focal functional
differences can be detected in the thalamo-prefrontal
network, though no morphometric differences were
detected between IGE subjects and normal controls. Our
results both point to underlying functional
abnormalities in IGE and highlight the power of MRI to
better characterize neurological disease.
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