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Abstract #1371

Multimodal quantitative imaging detects functional but not structural abnormalities in idiopathic generalized epilepsy

Megan L. McGill 1 , Orrin Devinsky 2 , Xiuyuan Wang 2 , Brian T. Quinn 2 , Heath Pardoe 2 , Chad Carlson 2 , Tracy Butler 2 , Ruben Kuzniecky 2 , and Thomas Thesen 2

1 Radiology, New York University School of Medicine, New York, NY, United States, 2 Comprehensive Epilepsy Center, Neurology, New York University School of Medicine, New York, NY, United States

This study employs functional and anatomic analysis of MRI scans to detect focal and network abnormalities in Idiopathic Generalized Epilepsy (IGE), a diffuse neurologic disorder characterized by normal appearing clinical MRI scans. Analysis of resting state functional MRI, diffusion tensor imaging, and quantitative morphometric analysis shows that focal functional differences can be detected in the thalamo-prefrontal network, though no morphometric differences were detected between IGE subjects and normal controls. Our results both point to underlying functional abnormalities in IGE and highlight the power of MRI to better characterize neurological disease.

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