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Abstract #1425

TOWARDS PRECISION NEUROIMAGING: STANDARDIZATION OF DTI OF A MULTICENTER TRAUMATIC BRAIN INJURY STUDY

Eva M Palacios 1 , Alastair J Martin 1 , Frank Ezekiel 1 , Esther L Yuh 1 , Geoffrey T Manley 2 , and Pratik Mukherjee 1

1 Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States, 2 Neurological Surgery, San Francisco General Hospital, San Francisco, California, United States

Each year, an estimated 1.7 million Americans sustain traumatic brain injury (TBI), often resulting in devastating neurological disabilities. TRACK-TBI is an NIH-funded study with the goal to create a large, high quality neuroimaging and clinical database. Diffusion tensor imaging (DTI) has shown promise in prior single-center studies and a major objective of TRACK-TBI is to validate its utility. A critical need for a multicenter imaging study is to minimize the inter-site variability of quantitative neuroimaging biomarkers. In this work, we present initial results that suggest the feasibility of standardizing DTI across 3T scanners in a large-scale neuroimaging research study.

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