Abstract #1425
TOWARDS PRECISION NEUROIMAGING: STANDARDIZATION OF DTI OF A MULTICENTER TRAUMATIC BRAIN INJURY STUDY
Eva M Palacios 1 , Alastair J Martin 1 , Frank Ezekiel 1 , Esther L Yuh 1 , Geoffrey T Manley 2 , and Pratik Mukherjee 1
1
Radiology and Biomedical Imaging, University
of California San Francisco, San Francisco, California,
United States,
2
Neurological
Surgery, San Francisco General Hospital, San Francisco,
California, United States
Each year, an estimated 1.7 million Americans sustain
traumatic brain injury (TBI), often resulting in
devastating neurological disabilities. TRACK-TBI is an
NIH-funded study with the goal to create a large, high
quality neuroimaging and clinical database. Diffusion
tensor imaging (DTI) has shown promise in prior
single-center studies and a major objective of TRACK-TBI
is to validate its utility. A critical need for a
multicenter imaging study is to minimize the inter-site
variability of quantitative neuroimaging biomarkers. In
this work, we present initial results that suggest the
feasibility of standardizing DTI across 3T scanners in a
large-scale neuroimaging research study.
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